Gastroenterology , News
17 августа, 2024

Hepatitis C Virus NS5A and Core Protein Induce Fibrosis-Related Gene Regulation in Huh7 Cells Through Activation of LX2 Cells

Introduction Hepatocellular carcinoma (HCC) is the primary form of liver cancer and the second leading cause of cancer-related deaths globally, with approximately 140,000 cases attributed to chronic hepatitis C virus (HCV) infection. HCV is a hepatotropic positive-sense RNA virus that encodes a polyprotein, generating various structural and non-structural proteins. Chronic liver damage leads to unregulated […]

Gastroenterology , News
15 августа, 2024

Interplay Between Drug-Induced Liver Injury and Gut Microbiota: A Comprehensive Overview

Introduction Recent research has revealed a close association between drug-induced liver injury (DILI) and gut microbiota. However, the specific mechanisms of gut microbiota involvement in DILI remain unclear. This review examines how gut microbiota interacts with common hepatotoxic drugs and its potential role in DILI pathogenesis, offering a comprehensive reference for the interplay between DILI […]

Gastroenterology , News
1 августа, 2024

Top 5 Shocking Facts About Fatty Liver Disease: A Dietitian’s Perspective

Introduction Fatty liver disease, also known as non-alcoholic fatty liver disease (NAFLD), is becoming one of the most serious threats to modern healthcare. In recent years, we have observed an alarming increase in cases of fatty liver disease, affecting not only adults but also children. First described as a medical concept in the mid-20th century, […]

Gastroenterology , News
10 июля, 2024

Hepatitis Under Control: How New Methods Are Saving Lives

Introduction Hepatitis remains one of the major global medical challenges. As of 2023, over 296 million people worldwide live with chronic hepatitis B, and 58 million suffer from chronic hepatitis C. These diseases pose a serious threat to health, causing a wide range of complications, from liver cirrhosis to liver cancer. Hepatitis B: The Scope […]

News
5 июня, 2024

In terms of risk, is a low or high level of SHBG more problematic?

It is unclear who this individual is. The biological effects of sex steroid hormones are significantly influenced not by their total blood fraction, but rather by the plasma concentration of free (bioavailable) steroids.The levels of SHBG (a trap protein that irreversibly binds testosterone) and albumin were also measured. It is important to consider this when […]

Gastroenterology
5 июня, 2024

Study Global Burden of Disease: a germ, but more than 1 million deaths

Erkenntnis 5 bacterial pathogens – Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Klebsiella pneumoniae and Pseudomonas aeruginosa – were collectively responsible for over 50 % of global bacterial deaths in 2019. Why this matters Prevention measures and, especially in very young patients, visits to the doctor should be called upon if infections are suspected. Key results 33 investigated bacterial pathogens were in […]

Cardiology
3 июня, 2024

A young man with a smart watch

With a smartwatch for a few hundred euros, wearers can derive a simple ECG (1-lead electrocardiogram). This should serve their “heart health”, for example, by detecting atrial fibrillation and timely stroke prevention  can be initiated. However, such a smart watch can also harm the health of the wearer, as now confirmed by the medical history […]

Otolaryngology
1 июня, 2024

Elderly cirrhosis patients: In search of the cause of dementia

Dementia symptoms often occur along with hepatic encephalopathy (HE) in patients with cirrhosis of the liver, a recent study shows. “As patients with cirrhosis age, we encounter numerous individuals who may be susceptible to both diseases,” said lead author Dr. Jasmohan Bajaj, a professor of gastroenterology, hepatology and nutrition at Virginia Commonwealth University Medical Center […]

Gastroenterology
23 мая, 2024

Some patients with neuroendocrine tumors prefer quality of life over longevity

Patients with neuroendocrine tumors, who may have a much longer life expectancy than those with aggressive tumors, report prioritizing quality of life (QoL) factors, such as remaining independent, rather than longer survival. However, they believe that doctors often do not share their priorities, according to a study published in Journal of the National Comprehensive Cancer […]

Otolaryngology
17 мая, 2024

Melanoma or advanced NSCLC: immune checkpoint inhibitors for octogenarians?

Conclusions A retrospective cohort indicates that patients aged ≥80 years have reasonably good survival and safety outcomes with immune checkpoint inhibitor (ICI) inhibitors for melanoma or non-small cell lung cancer (non-small cell lung cancer, NSCLC) in advanced stages, but 18.5% discontinue treatment due to grade 3–4 toxicity. Why it matters The first real-world study on the […]