21 декабря, 2020

Higher risk of stroke in young adults with moderate to heavy alcohol consumption

Knowledge

  • The higher the number of years in which young adults consume moderately to heavily, the higher their risk of stroke, especially the risk of hemorrhagic stroke.

Why this matters

Study design

  • Korean, nationwide population-based cohort study with 1,536,668  adults aged 20–39  years that underwent 4-_ annual health examinations in 2009–2012.
  • Participants were assigned one point for each year of moderate to heavy alcohol consumption (≥ 105 g/week), resulting in a cumulative alcohol load value of  0–4.
  • Main result: Emerging stroke
  • Funding: Korea Medical Device Development Fund, other sponsors

Key results

  • During median follow-up of 6  years, 0.21 % of young adults had a stroke, resulting in an incidence rate of 0.37 per 1,000  person-years.
  • Compared to peers with a cumulative alcohol load value of  0 young adults with a value of 2, 3 and 4 had a value of 19 %, 22 % and 19 %, respectively.23 % higher risk of stroke.
  • This association was mainly caused by hemorrhagic strokes and not ischemic strokes.
  • Compared to peers with a cumulative alcohol load value of  0 young adults with a score of 2, 3 and 4 had a 30 %, 42 % and 36 % higher risk of hemorrhagic stroke, respectively.
  • The effect of a higher score was attenuated in young adults who were hypertensive or a  BMI in the obese range.
  • When gender-specific alcohol consumption was taken into account instead, the associations were not significant in women.

Restrictions

  • Results may not be transferable to other groups of people.
  • Self-statements may have been influenced by memory distortion.
  • The group with a score of 0 drank lightly.

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