SIF Italian Society of Pharmacology Pharmacogenetics n.154 of OncologyImpact of genetic polymorphisms in ABCB1 and ABCG2 transporters and in genes regulating the transport and metabolism of xenobiotics PXR and CAR on the clinical efficacy of dasatinib in chronic myeloid leukemiaNeuropsychiatryImpact of NFIB and CYP1A gene variants on serum clozapine concentration – A retrospective naturalistic cohort […]
Il On 1 February, the Swedish Presidency of the Council of the European Union (EU) and the European Commission co-organised a cancer conference entitled ‘Equity, excellence and innovation: modern cancer care for all’, during which leading cancer experts from healthcare and academia and high-level political delegates discussed current cancer prevention strategies in the EU, ways […]
Source – https://www.univadis.de/viewarticle/patientenbefragungen-in-praxen-eher-selten
Knowledge Oral monotherapy with iptacopan was shown to be superior to intravenous anti-C5 antibodies in patients with paroxysmal nocturnal haemoglobinuria nocturnal haemoglobinuria (PNH) and residual anaemia. Iptacopan may represent a practice-changing outpatient treatment for suboptimal responses to standard treatment (SoC) and may be a preferred treatment option for all patients with hemolytic PNH. Why this […]
A meta-analysis reports a lower incidence of haematological toxicity than similar drugs. Context The immune checkpoint inhibitor nivolumab is approved in the United States and Europe for at least 10 types of cancer, including melanoma, non-small cell lung cancer, renal cell carcinoma, and gastric cancers. Nivolumab works by inhibiting the immunosuppressive molecule programmed cell death protein […]
Computed Tomography protocols for clinical indication In the document the essential elements relating to the technical settings of the various districts and apparatuses examined have been considered, taking into account the most frequent clinical pathologies. The draft was drawn up in the full awareness of not being able to prepare a document that reported all […]
Findings In patients with newly diagnosed acute B-cell acute lymphoblastic leukemia (B-ALL) without measurable minimal residual disease (MRD-negative) after initial treatment, the use of blinatumomab in addition to consolidation chemotherapy resulted in a significant improvement in overall survival (OS). This consolidation therapy may represent a new standard of care for this patient population. Why this matters Although […]
Colonoscopy screening reduces the incidence and mortality of colorectal cancer (CCR) by enabling detection and removal of precancerous lesions. However, the available evidence on the optimal screening interval is limited. In 2019, a systematic review and meta-analysis on the topic showed that the detection of advanced malignancies within 10 years of a negative screening colonoscopy […]
Leipzig/Berlin (pag) – The German Depression Aid and Suicide Prevention Foundation (DDH) has published the results of this year’s Germany Barometer Depression. Accordingly, 23 percent of respondents currently suffer from a diagnosed depression, eight percent fall ill every year. Prof. Ulrich Hegerl, Chairman of the DDH, points out treatment offers and talks to those affected. […]
AIFA Agenzia Italiana del Farmaco Pharmaceutical expenditure monitoring AIFA makes available the documents relating to the monthly monitoring of national and regional pharmaceutical expenditure for the period January / December 2021 (consultative) and January / February 2022. Published on: – All rights reserved and for personal use– Download the full document in PDF format from […]