Key messages Sotorasib shows antitumor activity in patients with pancreatic cancer KRAS p.G12C mutated already undergoing other treatments. The security profile appears acceptable. Pancreatic cancer remains one of the most lethal. In recent times, research efforts are focusing, rather than on the identification of new chemotherapy regimens to be used in all patients indiscriminately, on […]
Ministry of Health Ordinance — Official Gazette n.305 of Extension of urgent measures for the containment and management of the Covid-19 epidemic concerning the use of respiratory protective devices THE MINISTER OF HEALTH Having regard to Articles 32, 117, comma 2, letter q), e 118 of the Constitution; Having regard to the […]
AIFA Agenzia Italiana del Farmaco Web activation and publication of monitoring cards — Registro Imfinzi (ES SCLC) Users of the Drug Registries subject to Monitoring are informed that, following the publication of the AIFA Determine in the OJ no. 259 of , starting from the it is possible to use, under the NHS reimbursement scheme, […]
The Joint Federal Committee (G-BA) has passed a resolution on the evaluation of the appropriate comparator therapy for Voxelotor (Oxbryta, Global Blood Therapeutics Germany GmbH) for the treatment of hemolytic anaemia due to sickle cell disease as monotherapy or in combination with hydroxycarbamide in adults, children and adolescents from the age of 12 years: Voxelotor […]
National register of breast implants Report pilot phase 25 March 2019 — The presence and implementation of registers in which information and data relating to diseases and their treatment converge are undoubtedly a strong point in view of the essential (and continuous) process of improvement of the system as a whole. Operating in an articulated […]
AIFA Agenzia Italiana del Farmaco Web activation and publication of monitoring cards — Registro Opdivo (mCRC) Users of the Drug Registries subject to Monitoring are informed that, following the publication of the AIFA Determine in the OJ no. 256 of , starting from the it is possible to use, under the NHS reimbursement scheme, OPDIVO […]
AIFA Agenzia Italiana del Farmaco Important Information Note on Caprelsa (vandetanib) Deficiency of Caprelsa (vandetanib) 100 mg and 300 mg film-coated tablets. Summary: There is currently a temporary shortage of Caprelsa (vandetanib) 100 mg and 300 mg film-coated tablets in Italy. The availability of the medicine is limited and at the moment its supply takes […]
A large Danish prospective cohort study found that increasing levels of fecal hemoglobin (f-Hb) are associated with an increase of 30 %–250 % of deaths from non-colorectal cancer (CRC), respiratory disease and cardiovascular disease (CVD). Why this matters The results of one of the largest studies of their kind suggest that f-Hb screening could be useful beyond […]
SIF Societa’ Italiana di Farmacologia Severe cutaneous adverse reactions Edited by Alessandra Russo. Specialist in Medical Toxicology. Messina An article on severe skin adverse reactions associated with pharmacological treatments was published in the Australian Prescriber journal. Below is a summary of the cutaneous adverse reactions and drugs mainly involved — All rights reserved and for […]
SIF Italian Society of Pharmacology Pharmacogenetics n.154 of OncologyImpact of genetic polymorphisms in ABCB1 and ABCG2 transporters and in genes regulating the transport and metabolism of xenobiotics PXR and CAR on the clinical efficacy of dasatinib in chronic myeloid leukemiaNeuropsychiatryImpact of NFIB and CYP1A gene variants on serum clozapine concentration – A retrospective naturalistic cohort […]