Vedolizumab, a monoclonal antibody has a higher 1- and 2-year persistence compared to two tumor necrosis factor inhibitors (anti-TNF, TNFi) in both Crohn’s disease and ulcerative colitis, according to the results of a meta-analysis. The result mainly affects bionaive patients; the advantage of vedolizumab over the two TNFis—infliximab and adalimumab—was more pronounced in ulcerative colitis […]
Phase IV trial is also known as a postmarketing surveillance trial. It includes long-term monitoring to identify any side effects or other health-threatening factors. Sometimes rare or long-term adverse effects develop over longer time period than is possible to detect during the Phase III clinical trials. The main purpose of Phase IV CT: • Establish […]
Uno study published on American Journal of Gastroenterology suggests that changes in smoking habits, alcohol consumption, body weight, and physical activity may modify the risk of developing colorectal cancer (CRC). “This is a message that physicians and gastroenterologists can give to patients and CRC screening participants to improve CRC prevention,” write Edoardo Botteri, PhD, Norway […]
Key messages There are people with incorrectly diagnosed diabetes mellitus all over the world. And in completely extraordinary cases, the diagnosis comes thanks to or because of other problems. An exemplary case was described by the surgeon Gerhard Rümenapf and colleagues of the Upper Rhine Vascular Center at the Diakonissen Foundation Hospital. The patient and […]
Milan, 1 Mar. (Adnkronos Salute) – A new life, without more pain and with 15 centimeters gained in height. This is how Linda, an invented name, was reborn, a 16-year-old who underwent back surgery last November at the Rizzoli-Ior Orthopedic Institute in Bologna for a severe combined form of scoliosis and kyphosis (idiopathic kyphoscoliosis) that […]
Key messages In patients with sepsis of unclear etiology, it is advisable to look for the cause; because an early diagnosis of the cause of sepsis can be prognostically very relevant, as the medical history of a man shows, the Chinese doctors from the “Mianyang Central Hospital” in the journal “BMC Infectious Diseases” describe. The patient […]
AIFA Agenzia Italiana del Farmaco Modify Veklury Register (remdesivir) early treatment Users of the Drug Registries subject to Monitoring are informed that, following the CTS decision, the Registry of the medicinal product Veklury (remdesivir), under the NHS reimbursement regimen, has been amended for the following therapeutic indication: Treatment of coronavirus disease 2019 (COVID-19), adult and […]
People with While inflammatory bowel disease (IBD) often has skin symptoms related to their intestinal disease, few scientists have studied how common they are. Nearly one-third of patients with ulcerative colitis or Crohn’s disease develop skin lesions — such as psoriasis, eczema and erythema nodosum — related to their condition, according to the prospective, monocentric […]
Key messages On a pseudoaneurysm of the superior thyroid artery as “very rare cause of throat swelling” Dr. Jiri Podzimek and colleagues from the Bad Salzungen Hospital. Such a pseudoaneurysm is dangerous because it can rupture. This can have fatal consequences, such as obstruction of the airways, Podzimek and his colleagues explain.The reason for the […]
Knowledge The pooled analysis of 18 studies with more than 430,000 participants in a meta-analysis found that obstructive sleep apnea (OSA) is associated with a 36% increase in cancer risk. In the subgroup of patients with moderate to severe OSA, the risk was significantly higher, namely more than twice as high , while there was […]