A meta-analysis of the best observational data revealed no association. Findings Current evidence suggests that taking proton pump inhibitors (PPIs) is not correlated with an increased risk of gastric cancer. For physicians considering discontinuing PPI treatment, the authors advise the same approach as in the recent proposal by the American Gastroenterological Association: to check whether there […]
Bepirovirsen is an antisense oligonucleotide that targeting all hepatitis B virus (HBV) messenger RNAs to reduce the levels of viral proteins. A phase 2b, randomized, investigator-unblinded trial was conducted involving participants with chronic HBV infection who were receiving or not receiving nucleoside or nucleotide analogue (NA) therapy. Participants were randomly assigned (in a 3:3:3:1 ratio) […]
SIF Societa’ Italiana di Farmacologia Nightmares associated with metformin treatment Edited by Alessandra Russo. Specialist in Medical Toxicology. Messina Clinical case A 40-year-old man with diabetes reported that in the last 3 weeks almost every night he had nightmares. A month earlier he had started taking metformin (500 mg BID), combined with an appropriate diet […]
The The team behind the messenger RNA (mRNA) vaccine Pfizer/BioNTech says personalized mRNA cancer vaccines could be available within the next decade. In an interview with BBC News, Professors Ugur Sahin and Ozlem Tureci revealed that they have been working on a cancer vaccine since before the pandemic and have had some promising results. The […]
Conclusions According to a 16 year-old nationwide population study conducted in Taiwan, women taking proton pump inhibitors (PPIs) may have a lower risk of developing female cancers. The risk reduction is greatest for breast and ovarian cancers in women aged 20 to 64 years and for cervical and endometrial cancers in women aged 40 to 64 years. No […]
In According to a new study, researchers found that eating grapes protects skin from ultraviolet (UV) damage. Study participants showed increased resistance to sunburn after consuming about 2 cups of grapes daily for 2 weeks. In this study, which involved 29 volunteers, researchers investigated the effect of consuming whole grape powder equivalent to an amount […]
Semaglutide caused the highest rates of GI symptoms, while liraglutide was associated with more pain in the upper abdomen. Findings In adverse event reports (UEs) in the U.S., glucagon-like peptide-1 receptor agonists (GLP-1RAs) were significantly associated with gastrointestinal (GI) UEs. Semaglutide was associated with the greatest risk of nausea, diarrhea, vomiting, constipation and pancreatitis, while liraglutide was more […]
A meta-analysis of the best observational data revealed no association. Findings Current evidence suggests that taking proton pump inhibitors (PPIs) is not correlated with an increased risk of gastric cancer. For physicians considering discontinuing PPI treatment, the authors advise the same approach as in the recent proposal by the American Gastroenterological Association: to check whether there […]
New Research suggests that the increased cancer risk of patients with diverticular disease is not limited to the gastrointestinal tract. A study published in Journal of the National Cancer Institute shows that these patients also have a 50% increased risk of lung cancer. The study included 75,704 patients diagnosed with diverticular disease and colorectal histopathology […]
Erkenntnis Constipation appears to increase the risk of first-time pyelonephritis and recurrent urinary tract infections (UTIs) in children without obvious abnormalities of the kidneys or urinary tract. Why this matters For all children aged> 4 Years after the first episode of pyelonephritis, a systematic assessment of bowel and bladder function undertakes. Key results There were 105 […]