Gastroenterology

Introduction Autoimmune liver diseases (AILDs) such as autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) are chronic inflammatory disorders affecting the hepatobiliary system. These diseases account for a small percentage of liver transplants (LT) in the United States, with survival outcomes influenced by various factors including disease burden, medical comorbidities, and […]

Introduction Hepatocellular carcinoma (HCC) is the primary form of liver cancer and the second leading cause of cancer-related deaths globally, with approximately 140,000 cases attributed to chronic hepatitis C virus (HCV) infection. HCV is a hepatotropic positive-sense RNA virus that encodes a polyprotein, generating various structural and non-structural proteins. Chronic liver damage leads to unregulated […]

Introduction Recent research has revealed a close association between drug-induced liver injury (DILI) and gut microbiota. However, the specific mechanisms of gut microbiota involvement in DILI remain unclear. This review examines how gut microbiota interacts with common hepatotoxic drugs and its potential role in DILI pathogenesis, offering a comprehensive reference for the interplay between DILI […]

Introduction Liver cirrhosis is a complex and potentially fatal disease resulting from chronic inflammatory processes. This condition is characterized by the replacement of healthy liver cells with fibrous scar tissue, rendering the organ unable to perform its essential functions. According to the World Health Organization, liver cirrhosis claims the lives of 40 million people worldwide […]