Cardiology

SIF Societa’ Italiana di Farmacologia FarmacoGenetica n.155 — OncologyWide association study between NUDT15 polymorphisms and mercaptopurine tolerance in a Japanese paediatric cohort with acute lymphoblastic leukemiaNeuropsychiatryPharmacogenetics-guided administration of clozapine based on HLA-DQB1, HLA-B and SLCO1B3-SLCO1B7 variantsImmunomodulationPharmacogenomics of genes encoding for methotrexate pathway proteins in rheumatoid arthritis patients: an approach towards personalized medicineNeonatologyPharmacogenetics may explain some […]

MK-0616, an oral PCSK9 inhibitor, met its primary endpoint in a Phase 2 study, significantly reducing LDL cholesterol levels in patients with hypercholesterolemia at doses of 6 mg to 30 mg compared to placebo. ApoB and non-HDL cholesterol levels have also been reduced. «These data support the further development of MK-0616, which may improve access […]

Background Several epidemiological studies suggested a link between cardiovascular disease (CVD) and the development of lung cancer, but were methodologically deficient. Insight A new, more rigorous study found that CVD is associated with a 67% higher risk of lung cancer and a 95% higher risk of death from lung cancer.The study was a nationwide matched […]

Palermo, Nov. 4. (Adnkronos Salute) — After 12 years, pediatric cardiac surgery returns to Palermo thanks to an alliance between two prestigious health facilities in Northern and Southern Italy. It was signed this morning at Palazzo d’Orléans, in Palermo, in the presence of the president of the Sicilian Region, Renato Schifani, and the vice president […]

A robust meta-analysis provides evidence of class I in favor of antihypertensive treatment. Knowledge Elderly patients with hypertension whose blood pressure-_(BP) is effectively treated with medication have a lower risk of developing dementia. Dementia prevention thus provides another reason for the treatment of hypertension, in addition to the positive effect on cardiovascular risk. Why this matters […]

AIFA Agenzia Italiana del Farmaco Hepatitis C: update of the on enrolled patients The Italian Medicines Agency makes available the weekly update of the data relating to treatments with the new second-generation direct antiviral drugs (DAAs) for the treatment of chronic hepatitis C, collected by the AIFA Monitoring Registers. Published on: — All rights reserved […]

Rome, March 7. (Adnkronos Health) — «Investing in prevention means investing in health, having fewer sick people and a more sustainable National Health Service. When we talk about chronic-degenerative diseases we are talking about cardiovascular and nephrological diseases that in most cases recognize diabetes, obesity and hypertension as causes. Therefore, by adopting correct lifestyles we […]

Stem cell therapies Vademecum to help patients and families To help patients and families to orient themselves and avoid more easily baseless promises and scams that aim only to enrich those who envisage «miracle cures», Osservatorio Terapie Avanzati (OTA) provides a vademecum in ten points. The focus is on stem cell-based therapies, an area of […]

Patients with diabetic neuropathy had both pain relief and neurological improvements 2-_ years after the start of spinal cord stimulation with 10-kHz. This is according to research published prior to its presentation at the annual meeting of the American Academy of Neurology. The results are based on the longest available follow-up to spinal cord stimulation […]

Large international cohort study finds «insufficient evidence of excessive harm» from this off-label application. Knowledge Intravenous thrombolysis (IVT) appeared in patients with ischemic stroke who had occurred in the last 48  hours of direct oral anticoagulant nbsp (DOAC) were not associated with an excessive risk of symptomatic intracranial haemorrhage. Why this matters US-American and European Guidelines […]