Normal weight does not protect against cardiometabolic diseases

Erkenntnis

• Persons with «normal» body weight have cardiometabolic problems as often as obese persons.
• Normal body weight does not exclude an unhealthy metabolic state.
• The authors advise conducting metabolic screening in people of any weight.

Why this matters

• Metabolic syndrome, which includes insulin resistance, high blood pressure, dyslipidemia and inflammation, can be present in both normal-weight and obese individuals.

Study design

• Meta-analysis of 41 prospective cohort studies (n = 4,028,750)
• The studies compared the incidence of cardiometabolic problems in metabolically unhealthy normal-weight (MUH-NW) adults with those in metabolically healthy obese people (MH-O).
• Result: Mortality, cardiac events
• Funding: None

Key results

• Compared to individuals with MH-O, individuals with MOH-NW had significantly higher rates of:
  • Mortality of any cause
  • Cardiovascular mortality
  • Severe adverse cardiac Events
• These relationships appeared to be mediated by diabetes.
• In addition, the rates of all 3-_ Results are similar in individuals with unhealthy metabolism and obesity, as well as in individuals with MOH-NW.

• Mortality of any cause
• Cardiovascular mortality
• Severe adverse cardiac Events

Restrictions

• Large heterogeneity between the studies considered

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