Second A new study, researchers have found that consuming grapes protects against skin damage induced by ultraviolet (UV) light. Study participants showed increased resistance to sunburn after consuming about 330 g (2 cups according to Anglo-Saxon measurement) of grapes every day for 2 weeks.
In this survey, which involved 29 volunteer subjects, researchers examined the effect of consuming whole grape powder equivalent to 380 g (2.25 cups) of grapes per day for 14 days against photodamage caused by UV light.
The participants’ skin response to UV light was measured before and after consuming grapes for 2 weeks by determining the threshold dose of UV radiation that induced visible redness after 24 hours, the so-called minimal erythema dose (MED).
Ultimately, one-third of the participants (n=9) showed greater skin resistance to UV irradiation after consuming the equivalent of 3 servings of grapes per day for 2 weeks.
About 3 of the 9 participants who gained UV resistance after consuming grapes showed a lasting response.
A metabolomic analysis of the gut microbiome, blood samples and urine samples was also performed to explore potential correlations with the gut-skin axis.The researchers found that participants who showed UV resistance had significant differences in microbiome and metabolome compared to patients who did not respond, suggesting a correlation between gut and skin.
Although the alpha and beta diversity of the gut microbiome was not altered, grape consumption has been shown to modulate microbiota abundance, enzyme levels, and Kyoto encyclopedia pathways of genes and genomes (Kyoto Encyclopedia of Genes and Genomes). The study authors attribute these effects to naturally occurring polyphenols in grapes.
«It is little if the modulation of the gut-skin axis results in an increase in UV resistance, but there is a correlation. More generally, it is reasonable to expect that these mechanisms are related to other health outcomes that are expected to result from grape consumption,» the authors state.
In particular, a decrease in 3 urinary metabolites, 2′-deoxyribonic acid, 3-hydroxyphenyl acetic acid and scyllo-inositol was observed in the UV-resistant group.One metabolite in particular (2′-deoxyribonic acid) has proven to be a strong indicator of reduced photodamage and suggests characteristic genetic profiles important for personalised medicine. A cutaneous UV MED receiver operating characteristic curve, obtained for responders versus non-responders, revealed a 71.8% probability that urinary levels of 2′-deoxyribonic acid identify a cutaneous non-responder to UV rays.
The authors concluded that a segment of the population can achieve greater resistance to a UV-induced dermal response due to grape consumption.
Commenting on the results, lead author John Pezzuto said: «The phrase ‘Let food be your medicine and medicine be your food’ goes back to Hippocratic times. Today, 2500 years later, we are still learning how true this claim is, as this human study conducted with food grapes demonstrates.»
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Source — https://www.univadis.it/viewarticle/mangiare-uva-puo-proteggere-dal-tumore-cutaneo