In According to a new study, researchers found that eating grapes protects skin from ultraviolet (UV) damage. Study participants showed increased resistance to sunburn after consuming about 2 cups of grapes daily for 2 weeks.
In this study, which involved 29 volunteers, researchers investigated the effect of consuming whole grape powder equivalent to an amount of 2.25 cups of grapes per day over a 14-day period against photodamage caused by UV light.
Participants’ skin response to UV light was measured before and after eating grapes over a two-week period by determining the threshold dose of UV radiation that caused visible redness after 24 hours the minimum erythema dose (MED).
Ultimately, one-third of participants (n=9) showed greater skin resistance to UV radiation after consuming the equivalent of 3 servings of grapes per day for 2 weeks.
About 3 of the 9 participants who acquired UV resistance after eating grapes showed a durable response.
A metabolome analysis of the gut microbiome, blood samples, and urine samples was also performed to investigate a possible relationship with the gut-skin axis.The researchers found that the participants who had UV resistance showed significant differences in microbiome and metabolome compared to non-responders, suggesting a correlation between gut and skin.
While the alpha and beta diversity of the gut microbiome did not change, grapes consumption was shown to modulate microbiotic diversity, enzyme levels, and signaling pathways of the Kyoto Encyclopedia of Genes and Genomes. The authors of the study attribute this to the naturally occurring polyphenols in grapes.
«It is uncertain whether modulation of the gut-skin axis leads to increased UV resistance, but there is a link. More broadly, these mechanisms can be assumed to be associated with other health effects of grape consumption,» the authors said.
In particular, the three metabolites in urine 2′-deoxyribonic acid, 3-hydroxyphenyl acetic acid and scyllo-inositol, were decreased in the UV-resistant group.One metabolite in particular (2′-deoxyribonic acid) proved to be a strong indicator of less light damage, suggesting unique genetic profiles that are important for personalized medicine, the researchers said. A receiver-operating-characteristic curve derived from responders versus non-responders for skin MED by UV revealed a 71.8% probability that urine levels of 2′-deoxyribonic acid identified UV non-responders.
The authors concluded that by eating grapes, a portion of the population may achieve greater resistance to a skin reaction triggered by UV irradiation.
John Pezzuto, the lead author of the study, commented on the results with the words: «The sentence ‘Leave the Be your medicine and Medicine your food’ dates back to the time of Hippocrates.Now, after 2500 years, and as this human study conducted with grapes shows, we are still in the process of experiencing the reality of this statement.»
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Source — https://www.univadis.de/viewarticle/weintrauben—ein-schutz-vor-uv-bedingten-hautschaden