Erkenntnis
- In patients with clinically localized Bladder carcinoma is a poor nutritional status according to Controlling Nutritional Status (CONUT) score independently associated with poorer postoperative morbidity and mortality.
Why this matters
- CONUT is simple and cost-effective and can contribute to stratification and treatment decisions through preoperative patient evaluation.
Study design
- Study of 347 patients with clinically localized bladder cancer who underwent radical cystectomy between 2005 and 2019.
- The CONUT score was defined as an algorithm that included serum albumin, total lymphocyte count, and cholesterol.
- A threshold to distinguish between low and high CONUT score was determined by calculating the ROC (Receiver Operating Characteristic) curve.
- Funding: none.
Key results
- The area under the curve was 0.72, so the limit for the CONUT score was set to 3.
- 32.3% of patients had a high CONUT score of ≥3.
- A high CONUT score was associated with a significantly higher rate of complications of any grade (OR 3.58, P=0.001), serious complications (OR 2.56, P=0.003), and readmission to hospital within 30 days (OR 2.39, P=0.01).
- The addition of the CONUT score to the reference models improved discrimination in predicting complications of any degree ( 4.0%, P=0.03) and serious complications ( 4.0%, P=0.04) as well as resumption within 30 days ( 5.0%, P=0.02).
- A high COUT score was associated with significantly worse recurrence-free survival (HR 2.57; P<0.001), overall survival (HR 2.37; P<0.001) and cancer-specific survival (HR 3.52; P<0.001).
Restrictions
- Retrospective design.
- Smoking status was unknown.
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Source — https://www.univadis.de/viewarticle/blasenkarzinom-ernahrungszustand-sagt-postoperative-ergebnisse-vorher
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